Positive Feedback Promotes Oscillations in Negative Feedback Loops
نویسندگان
چکیده
منابع مشابه
Positive Feedback Promotes Oscillations in Negative Feedback Loops
A simple three-component negative feedback loop is a recurring motif in biochemical oscillators. This motif oscillates as it has the three necessary ingredients for oscillations: a three-step delay, negative feedback, and nonlinearity in the loop. However, to oscillate, this motif under the common Goodwin formulation requires a high degree of cooperativity (a measure of nonlinearity) in the fee...
متن کاملModeling circadian oscillations with interlocking positive and negative feedback loops.
Both positive and negative feedback loops of transcriptional regulation have been proposed to be important for the generation of circadian rhythms. To test the sufficiency of the proposed mechanisms, two differential equation-based models were constructed to describe the Neurospora crassa and Drosophila melanogaster circadian oscillators. In the model of the Neurospora oscillator, FRQ suppresse...
متن کاملRobust, tunable biological oscillations from interlinked positive and negative feedback loops.
A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromisi...
متن کاملInterlinked positive and negative feedback loops design emotional sweating.
BACKGROUND The stereotyped nature of the skin conductance response (SCR) waveform has recently inspired several dynamic modeling approaches to the process of SCR. The suggested models differ: (i) in the order of the linear differential equation representing the process, and (ii) the neurobiological interpretation of the system parameters. While several research groups consider the sympathetic s...
متن کاملOscillation patterns in negative feedback loops.
Organisms are equipped with regulatory systems that display a variety of dynamical behavior ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein concentrations or gene expression levels are related to the presence of at least one negative feedback loop in the regulatory network. Here, we study the dynamic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0104761